Interazioni tra farmaci
Amoxicillin + Methotrexate
Gravità: Maggiore
Amoxicillin and Methotrexate: major interaction.
Ultimo aggiornamento Fonti: US FDA label
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Sintesi
Penicillins such as amoxicillin can reduce methotrexate clearance and have been reported to raise methotrexate levels, causing myelosuppression and mucositis. The effect is mainly reported with high-dose methotrexate and in renal impairment, and is less predictable with low-dose therapy. Evidence is based on case reports and pharmacokinetic observations.
Cosa significa questa interazione in parole semplici
Amoxicillin and Methotrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amoxicillin belongs to Anti Bacterial; Methotrexate belongs to Oncology.
Perché avviene
Penicillins compete with methotrexate for renal tubular secretion via organic anion transporters, reducing its elimination.
Cosa fare
Where possible choose an antibiotic with less renal interaction potential, particularly during high-dose methotrexate. If amoxicillin is needed, monitor full blood count, renal function and methotrexate levels where available.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Riferimenti
Altre interazioni di Methotrexate
- Acitretin + Methotrexate Controindicata
- Adenovirus types 4 and 7 live + Methotrexate Controindicata
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Controindicata
- Ketorolac + Methotrexate Controindicata
- Measles mumps and rubella vaccine live + Methotrexate Controindicata
- Measles mumps and rubella vaccine + Methotrexate Controindicata
Altre interazioni di Amoxicillin
- Amoxicillin + Bcg vaccine live Moderata
- Amoxicillin + Cholera vaccine Moderata
- Amoxicillin + Eravacycline Moderata
- Amoxicillin + Microbiota Moderata
- Amoxicillin + Mycophenolate Moderata
- Amoxicillin + Omadacycline Moderata
Domande frequenti
Can I take Amoxicillin with Methotrexate?
MediHelp rates the interaction as major. Amoxicillin and Methotrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Penicillins such as amoxicillin can reduce methotrexate clearance and have been reported to raise methotrexate levels, causing myelosuppression and mucositis. The effect is mainly reported with high-dose methotrexate and in renal impairment, and is less predictable with low-dose therapy. Evidence is based on case reports and pharmacokinetic observations.
How serious is the interaction between Amoxicillin and Methotrexate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible choose an antibiotic with less renal interaction potential, particularly during high-dose methotrexate. If amoxicillin is needed, monitor full blood count, renal function and methotrexate levels where available.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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