Interazioni tra farmaci
Aripiprazole + Thioridazine
Gravità: Controindicata
Aripiprazole and Thioridazine: contraindicated interaction.
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Sintesi
Thioridazine and aripiprazole each delay ventricular repolarisation, so using them together adds to the chance of marked QTc lengthening. This can precipitate torsades de pointes, particularly with hypokalaemia, bradycardia or structural heart disease.
Cosa significa questa interazione in parole semplici
Aripiprazole and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Aripiprazole belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Perché avviene
Additive QTc prolongation through hERG potassium channel blockade
Cosa fare
Do not co-prescribe; choose an agent without QT liability. If one must continue, obtain ECG and electrolytes first.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Thioridazine
- Abiraterone + Thioridazine Controindicata
- Adagrasib + Thioridazine Controindicata
- Amiodarone + Thioridazine Controindicata
- Amisulpride + Thioridazine Controindicata
- Amitriptyline + Thioridazine Controindicata
- Amoxapine + Thioridazine Controindicata
Altre interazioni di Aripiprazole
- Aripiprazole + Pimozide Controindicata
- Amisulpride + Aripiprazole Maggiore
- Aripiprazole + Arsenic trioxide Maggiore
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Maggiore
- Aripiprazole + Carbamazepine Maggiore
- Aripiprazole + Cisapride Maggiore
Domande frequenti
Can I take Aripiprazole with Thioridazine?
MediHelp rates the interaction as contraindicated. Aripiprazole and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine and aripiprazole each delay ventricular repolarisation, so using them together adds to the chance of marked QTc lengthening. This can precipitate torsades de pointes, particularly with hypokalaemia, bradycardia or structural heart disease.
How serious is the interaction between Aripiprazole and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-prescribe; choose an agent without QT liability. If one must continue, obtain ECG and electrolytes first.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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