Interazioni tra farmaci
Avanafil + Isosorbide mononitrate
Gravità: Controindicata
Avanafil and Isosorbide mononitrate: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Both avanafil and isosorbide mononitrate relax vascular smooth muscle through the nitric oxide-cGMP pathway. Their combination can cause profound, sometimes fatal, hypotension.
Cosa significa questa interazione in parole semplici
Avanafil and Isosorbide mononitrate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Avanafil belongs to Genitourinary; Isosorbide mononitrate belongs to Cardiovascular.
Perché avviene
PDE5 inhibition potentiates NO/cGMP vasodilation
Cosa fare
Contraindicated; do not give nitrates or nitroprusside within 12 hours of avanafil, and keep resuscitation capability available if nitrates are urgently needed later.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Avanafil
- Amyl nitrite + Avanafil Controindicata
- Atazanavir + Avanafil Controindicata
- Avanafil + Clarithromycin Controindicata
- Avanafil + Conivaptan Controindicata
- Avanafil + Darunavir Controindicata
- Avanafil + Fosamprenavir Controindicata
Altre interazioni di Isosorbide mononitrate
- Isosorbide mononitrate + Riociguat Controindicata
- Isosorbide mononitrate + Sildenafil Controindicata
- Isosorbide mononitrate + Tadalafil Controindicata
- Isosorbide mononitrate + Vardenafil Controindicata
- Ergotamine + Isosorbide mononitrate Maggiore
- Isosorbide mononitrate + Methylergonovine Maggiore
Domande frequenti
Can I take Avanafil with Isosorbide mononitrate?
MediHelp rates the interaction as contraindicated. Avanafil and Isosorbide mononitrate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both avanafil and isosorbide mononitrate relax vascular smooth muscle through the nitric oxide-cGMP pathway. Their combination can cause profound, sometimes fatal, hypotension.
How serious is the interaction between Avanafil and Isosorbide mononitrate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; do not give nitrates or nitroprusside within 12 hours of avanafil, and keep resuscitation capability available if nitrates are urgently needed later.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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