Interazioni tra farmaci
Isosorbide mononitrate + Riociguat
Gravità: Controindicata
Isosorbide mononitrate and Riociguat: contraindicated interaction.
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Sintesi
Riociguat stimulates soluble guanylate cyclase and nitrates supply nitric oxide, producing additive vasodilation. Severe, potentially life-threatening hypotension can result. Labeling contraindicates concomitant use of riociguat with nitrates in any form.
Cosa significa questa interazione in parole semplici
Isosorbide mononitrate and Riociguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isosorbide mononitrate belongs to Cardiovascular; Riociguat belongs to Cardiovascular.
Perché avviene
Additive cGMP-mediated vasodilation from nitric oxide donation and soluble guanylate cyclase stimulation.
Cosa fare
Do not co-administer. Use a non-nitrate antianginal while on riociguat.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Isosorbide mononitrate
- Avanafil + Isosorbide mononitrate Controindicata
- Isosorbide mononitrate + Sildenafil Controindicata
- Isosorbide mononitrate + Tadalafil Controindicata
- Isosorbide mononitrate + Vardenafil Controindicata
- Ergotamine + Isosorbide mononitrate Maggiore
- Isosorbide mononitrate + Methylergonovine Maggiore
Altre interazioni di Riociguat
- Avanafil + Riociguat Controindicata
- Dipyridamole + Riociguat Controindicata
- Isosorbide dinitrate + Riociguat Controindicata
- Nitroglycerin + Riociguat Controindicata
- Riociguat + Sildenafil Controindicata
- Riociguat + Tadalafil Controindicata
Domande frequenti
Can I take Isosorbide mononitrate with Riociguat?
MediHelp rates the interaction as contraindicated. Isosorbide mononitrate and Riociguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Riociguat stimulates soluble guanylate cyclase and nitrates supply nitric oxide, producing additive vasodilation. Severe, potentially life-threatening hypotension can result. Labeling contraindicates concomitant use of riociguat with nitrates in any form.
How serious is the interaction between Isosorbide mononitrate and Riociguat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Use a non-nitrate antianginal while on riociguat.
What other medicines interact with Isosorbide mononitrate?
MediHelp also lists interactions of Isosorbide mononitrate with, for example, Avanafil, Sildenafil, Tadalafil. The full list is on the Isosorbide mononitrate page.
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