Interazioni tra farmaci
Avanafil + Nitroglycerin
Gravità: Controindicata
Avanafil and Nitroglycerin: contraindicated interaction.
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Sintesi
Both avanafil and nitroglycerin relax vascular smooth muscle through the nitric oxide-cGMP pathway. Their combination can cause profound, sometimes fatal, hypotension.
Cosa significa questa interazione in parole semplici
Avanafil and Nitroglycerin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Avanafil belongs to Genitourinary; Nitroglycerin belongs to Cardiovascular.
Perché avviene
PDE5 inhibition potentiates NO/cGMP vasodilation
Cosa fare
Contraindicated; do not give nitrates or nitroprusside within 12 hours of avanafil, and keep resuscitation capability available if nitrates are urgently needed later.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Nitroglycerin
- Nitroglycerin + Riociguat Controindicata
- Nitroglycerin + Sildenafil Controindicata
- Nitroglycerin + Tadalafil Controindicata
- Nitroglycerin + Vardenafil Controindicata
- Dihydroergotamine intranasal + Nitroglycerin Maggiore
- Dihydroergotamine + Nitroglycerin Maggiore
Altre interazioni di Avanafil
- Amyl nitrite + Avanafil Controindicata
- Atazanavir + Avanafil Controindicata
- Avanafil + Clarithromycin Controindicata
- Avanafil + Conivaptan Controindicata
- Avanafil + Darunavir Controindicata
- Avanafil + Fosamprenavir Controindicata
Domande frequenti
Can I take Avanafil with Nitroglycerin?
MediHelp rates the interaction as contraindicated. Avanafil and Nitroglycerin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both avanafil and nitroglycerin relax vascular smooth muscle through the nitric oxide-cGMP pathway. Their combination can cause profound, sometimes fatal, hypotension.
How serious is the interaction between Avanafil and Nitroglycerin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; do not give nitrates or nitroprusside within 12 hours of avanafil, and keep resuscitation capability available if nitrates are urgently needed later.
What other medicines interact with Nitroglycerin?
MediHelp also lists interactions of Nitroglycerin with, for example, Riociguat, Sildenafil, Tadalafil. The full list is on the Nitroglycerin page.
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