Interazioni tra farmaci
Nitroglycerin + Riociguat
Gravità: Controindicata
Nitroglycerin and Riociguat: contraindicated interaction.
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Sintesi
Riociguat stimulates soluble guanylate cyclase and nitrates supply nitric oxide, producing additive vasodilation. Severe, potentially life-threatening hypotension can result. Labeling contraindicates concomitant use of riociguat with nitrates in any form.
Cosa significa questa interazione in parole semplici
Nitroglycerin and Riociguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Nitroglycerin belongs to Cardiovascular; Riociguat belongs to Cardiovascular.
Perché avviene
Additive cGMP-mediated vasodilation from nitric oxide donation and soluble guanylate cyclase stimulation.
Cosa fare
Do not co-administer. Use a non-nitrate option for angina or acute needs while on riociguat.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Nitroglycerin
- Avanafil + Nitroglycerin Controindicata
- Nitroglycerin + Sildenafil Controindicata
- Nitroglycerin + Tadalafil Controindicata
- Nitroglycerin + Vardenafil Controindicata
- Dihydroergotamine intranasal + Nitroglycerin Maggiore
- Dihydroergotamine + Nitroglycerin Maggiore
Altre interazioni di Riociguat
- Avanafil + Riociguat Controindicata
- Dipyridamole + Riociguat Controindicata
- Isosorbide dinitrate + Riociguat Controindicata
- Isosorbide mononitrate + Riociguat Controindicata
- Riociguat + Sildenafil Controindicata
- Riociguat + Tadalafil Controindicata
Domande frequenti
Can I take Nitroglycerin with Riociguat?
MediHelp rates the interaction as contraindicated. Nitroglycerin and Riociguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Riociguat stimulates soluble guanylate cyclase and nitrates supply nitric oxide, producing additive vasodilation. Severe, potentially life-threatening hypotension can result. Labeling contraindicates concomitant use of riociguat with nitrates in any form.
How serious is the interaction between Nitroglycerin and Riociguat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Use a non-nitrate option for angina or acute needs while on riociguat.
What other medicines interact with Nitroglycerin?
MediHelp also lists interactions of Nitroglycerin with, for example, Avanafil, Sildenafil, Tadalafil. The full list is on the Nitroglycerin page.
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