Interazioni tra farmaci
Axicabtagene ciloleucel + Sulphasalazine
Gravità: Moderata
Axicabtagene ciloleucel and Sulphasalazine: moderate interaction.
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Sintesi
Sulfasalazine has modest immunomodulatory activity and can cause cytopenias. CAR-T recipients have profound immune compromise and infection risk, and concurrent immunosuppressants may impair CAR-T expansion or add to toxicity.
Cosa significa questa interazione in parole semplici
Axicabtagene ciloleucel and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axicabtagene ciloleucel belongs to Oncology; Sulphasalazine belongs to Gastrointestinal Tract.
Perché avviene
Additive immunosuppression and possible myelosuppression, which may blunt CAR-T cell activity.
Cosa fare
Review the need for sulfasalazine around lymphodepletion and infusion, and hold it if possible. Monitor blood counts and infection.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Sulphasalazine
- Deferiprone + Sulphasalazine Maggiore
- Pexidartinib + Sulphasalazine Maggiore
- Sepiapterin + Sulphasalazine Maggiore
- Acalabrutinib + Sulphasalazine Moderata
- Aceclofenac + Sulphasalazine Moderata
- Acetazolamide + Sulphasalazine Moderata
Altre interazioni di Axicabtagene ciloleucel
Domande frequenti
Can I take Axicabtagene ciloleucel with Sulphasalazine?
MediHelp rates the interaction as moderate. Axicabtagene ciloleucel and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfasalazine has modest immunomodulatory activity and can cause cytopenias. CAR-T recipients have profound immune compromise and infection risk, and concurrent immunosuppressants may impair CAR-T expansion or add to toxicity.
How serious is the interaction between Axicabtagene ciloleucel and Sulphasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the need for sulfasalazine around lymphodepletion and infusion, and hold it if possible. Monitor blood counts and infection.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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