Interazioni tra farmaci
Axicabtagene ciloleucel + Azathioprine
Gravità: Maggiore
Axicabtagene ciloleucel and Azathioprine: major interaction.
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Sintesi
Azathioprine may impair T-cell function and reduce CAR-T cell expansion and efficacy. Concurrent immunosuppression also adds to infection risk after lymphodepletion.
Cosa significa questa interazione in parole semplici
Axicabtagene ciloleucel and Azathioprine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Axicabtagene ciloleucel belongs to Oncology; Azathioprine belongs to Gastrointestinal Tract.
Perché avviene
Immunosuppressive antimetabolite activity against lymphocytes may reduce CAR-T cell expansion and persistence.
Cosa fare
Discontinue azathioprine before leukapheresis and infusion as advised by the treating CAR-T center. Monitor for infections if immunosuppression cannot be stopped.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Controindicata
- Azathioprine + Bcg vaccine live Controindicata
- Azathioprine + Febuxostat Controindicata
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Controindicata
- Azathioprine + Measles mumps and rubella vaccine Controindicata
- Azathioprine + Measles mumps and rubella vaccine live Controindicata
Altre interazioni di Axicabtagene ciloleucel
Domande frequenti
Can I take Axicabtagene ciloleucel with Azathioprine?
MediHelp rates the interaction as major. Axicabtagene ciloleucel and Azathioprine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Azathioprine may impair T-cell function and reduce CAR-T cell expansion and efficacy. Concurrent immunosuppression also adds to infection risk after lymphodepletion.
How serious is the interaction between Axicabtagene ciloleucel and Azathioprine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Discontinue azathioprine before leukapheresis and infusion as advised by the treating CAR-T center. Monitor for infections if immunosuppression cannot be stopped.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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