Interazioni tra farmaci
Azathioprine + Febuxostat
Gravità: Controindicata
Azathioprine and Febuxostat: contraindicated interaction.
Ultimo aggiornamento Fonti: US FDA label
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Sintesi
Febuxostat inhibits xanthine oxidase and can raise levels of azathioprine's active metabolite, potentially causing severe bone marrow suppression. Labeling advises against use together because no safe dosing strategy is established. Patients with renal impairment or low TPMT activity are at particular risk.
Cosa significa questa interazione in parole semplici
Azathioprine and Febuxostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Azathioprine belongs to Gastrointestinal Tract; Febuxostat belongs to Genitourinary.
Perché avviene
Febuxostat inhibits xanthine oxidase, which is needed to inactivate 6-mercaptopurine, leading to accumulation of active thiopurine metabolites.
Cosa fare
Do not combine. Use an alternative urate-lowering approach, such as allopurinol with a substantial azathioprine dose reduction and close blood count monitoring, or another agent.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Riferimenti
- Febuxostat (Uloric) Prescribing Information - Drug Interactions — FDA Label
- Adenuric (febuxostat) Summary of Product Characteristics — EMA SmPC
Altre interazioni di Febuxostat
- Febuxostat + Mercaptopurine Controindicata
- Didanosine + Febuxostat Maggiore
- Apalutamide + Febuxostat Moderata
- Ethambutol + Febuxostat Moderata
- Febuxostat + Theophylline Moderata
Altre interazioni di Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Controindicata
- Azathioprine + Bcg vaccine live Controindicata
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Controindicata
- Azathioprine + Measles mumps and rubella vaccine Controindicata
- Azathioprine + Measles mumps and rubella vaccine live Controindicata
- Azathioprine + Measles mumps rubella and varicella vaccine live Controindicata
Domande frequenti
Can I take Azathioprine with Febuxostat?
MediHelp rates the interaction as contraindicated. Azathioprine and Febuxostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Febuxostat inhibits xanthine oxidase and can raise levels of azathioprine's active metabolite, potentially causing severe bone marrow suppression. Labeling advises against use together because no safe dosing strategy is established. Patients with renal impairment or low TPMT activity are at particular risk.
How serious is the interaction between Azathioprine and Febuxostat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use an alternative urate-lowering approach, such as allopurinol with a substantial azathioprine dose reduction and close blood count monitoring, or another agent.
What other medicines interact with Febuxostat?
MediHelp also lists interactions of Febuxostat with, for example, Mercaptopurine, Didanosine, Apalutamide. The full list is on the Febuxostat page.
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