Interazioni tra farmaci
Aztreonam + Cefoxitin
Gravità: Moderata
Aztreonam and Cefoxitin: moderate interaction.
Ultimo aggiornamento
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Sintesi
Cefoxitin can induce chromosomal beta-lactamases in some Gram-negative bacteria such as Enterobacter and Pseudomonas, which may reduce aztreonam activity. This is an in vitro antagonism, and its clinical relevance is uncertain.
Cosa significa questa interazione in parole semplici
Aztreonam and Cefoxitin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aztreonam belongs to Anti Bacterial; Cefoxitin belongs to Anti Bacterial.
Perché avviene
Cefoxitin induces inducible beta-lactamase production in some Gram-negative bacteria, which can hydrolyze aztreonam.
Cosa fare
Avoid pairing the two when treating organisms known to produce inducible beta-lactamases. Guide therapy by culture and susceptibility results.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Cefoxitin
- Amikacin + Cefoxitin Moderata
- Bcg vaccine live + Cefoxitin Moderata
- Cefoxitin + Chloramphenicol Moderata
- Cefoxitin + Cholera vaccine Moderata
- Cefoxitin + Dexamethasone-tobramycin Moderata
- Cefoxitin + Gentamicin Moderata
Altre interazioni di Aztreonam
Domande frequenti
Can I take Aztreonam with Cefoxitin?
MediHelp rates the interaction as moderate. Aztreonam and Cefoxitin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefoxitin can induce chromosomal beta-lactamases in some Gram-negative bacteria such as Enterobacter and Pseudomonas, which may reduce aztreonam activity. This is an in vitro antagonism, and its clinical relevance is uncertain.
How serious is the interaction between Aztreonam and Cefoxitin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid pairing the two when treating organisms known to produce inducible beta-lactamases. Guide therapy by culture and susceptibility results.
What other medicines interact with Cefoxitin?
MediHelp also lists interactions of Cefoxitin with, for example, Amikacin, Bcg vaccine live, Chloramphenicol. The full list is on the Cefoxitin page.
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