Interazioni tra farmaci
Cefoxitin + Chloramphenicol
Gravità: Moderata
Cefoxitin and Chloramphenicol: moderate interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Chloramphenicol is bacteriostatic and may reduce the bactericidal activity of beta-lactams such as cefoxitin in laboratory models. Clinical evidence of treatment failure is limited and mostly from older data in meningitis and severe infections. The concern is mainly for serious infections where rapid killing matters.
Cosa significa questa interazione in parole semplici
Cefoxitin and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefoxitin belongs to Anti Bacterial; Chloramphenicol belongs to Anti Bacterial.
Perché avviene
Pharmacodynamic antagonism: inhibition of bacterial protein synthesis by chloramphenicol may blunt the growth-dependent killing by beta-lactams.
Cosa fare
Avoid combining them for serious infections where bactericidal activity is needed; if both are required, monitor clinical response closely.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Cefoxitin e Chloramphenicol, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Cefoxitin
- Amikacin + Cefoxitin Moderata
- Aztreonam + Cefoxitin Moderata
- Bcg vaccine live + Cefoxitin Moderata
- Cefoxitin + Cholera vaccine Moderata
- Cefoxitin + Dexamethasone-tobramycin Moderata
- Cefoxitin + Gentamicin Moderata
Altre interazioni di Chloramphenicol
- Adagrasib + Chloramphenicol Maggiore
- Avapritinib + Chloramphenicol Maggiore
- Bcg vaccine live + Chloramphenicol Maggiore
- Benzhydrocodone / acetaminophen + Chloramphenicol Maggiore
- Chloramphenicol + Cobimetinib Maggiore
- Chloramphenicol + Colchicine Maggiore
Domande frequenti
Can I take Cefoxitin with Chloramphenicol?
MediHelp rates the interaction as moderate. Cefoxitin and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol is bacteriostatic and may reduce the bactericidal activity of beta-lactams such as cefoxitin in laboratory models. Clinical evidence of treatment failure is limited and mostly from older data in meningitis and severe infections. The concern is mainly for serious infections where rapid killing matters.
How serious is the interaction between Cefoxitin and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them for serious infections where bactericidal activity is needed; if both are required, monitor clinical response closely.
What other medicines interact with Cefoxitin?
MediHelp also lists interactions of Cefoxitin with, for example, Amikacin, Aztreonam, Bcg vaccine live. The full list is on the Cefoxitin page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
