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Interazioni tra farmaci

Amikacin + Cefoxitin

Gravità: Moderata

Amikacin and Cefoxitin: moderate interaction.

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Sintesi

Amikacin is nephrotoxic and ototoxic, and concurrent cephalosporins have been linked in some reports with additional kidney injury. Reduced renal function increases aminoglycoside accumulation and the risk of hearing damage.

Cosa significa questa interazione in parole semplici

Amikacin and Cefoxitin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Amikacin belongs to Anti Bacterial; Cefoxitin belongs to Anti Bacterial.

Livello di evidenza: Low

Perché avviene

Additive nephrotoxicity, with decreased renal clearance raising aminoglycoside exposure.

Cosa fare

Monitor serum creatinine and amikacin levels, and ask about hearing or balance symptoms. Adjust the amikacin dose to renal function.

Cosa chiedere al farmacista

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Amikacin with Cefoxitin?

MediHelp rates the interaction as moderate. Amikacin and Cefoxitin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amikacin is nephrotoxic and ototoxic, and concurrent cephalosporins have been linked in some reports with additional kidney injury. Reduced renal function increases aminoglycoside accumulation and the risk of hearing damage.

How serious is the interaction between Amikacin and Cefoxitin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin levels, and ask about hearing or balance symptoms. Adjust the amikacin dose to renal function.

What other medicines interact with Cefoxitin?

MediHelp also lists interactions of Cefoxitin with, for example, Aztreonam, Bcg vaccine live, Chloramphenicol. The full list is on the Cefoxitin page.

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