Interazioni tra farmaci
Baricitinib + Benzathine penicillin g
Gravità: Minore
Baricitinib and Benzathine penicillin g: minor interaction.
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Sintesi
Penicillins can inhibit OAT3, a transporter involved in baricitinib renal elimination, so baricitinib exposure may rise. Labeling advises against strong OAT3 inhibitors such as probenecid, but penicillin G is a much weaker inhibitor and benzathine penicillin gives low sustained levels, so the effect is likely small.
Cosa significa questa interazione in parole semplici
Baricitinib and Benzathine penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Baricitinib belongs to Musculoskeletal; Benzathine penicillin g belongs to Anti Bacterial.
Perché avviene
Possible weak OAT3 inhibition reducing renal tubular secretion of baricitinib.
Cosa fare
No dose change is generally needed; monitor for baricitinib adverse effects such as infection and cytopenias as usual.
Cosa chiedere al farmacista
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Altre interazioni di Benzathine penicillin g
- Benzathine penicillin g + Cholera vaccine Moderata
- Benzathine penicillin g + Microbiota Moderata
- Benzathine penicillin g + Omadacycline Moderata
- Benzathine penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderata
- Benzathine penicillin g + Vadadustat Moderata
- Amifampridine + Benzathine penicillin g Minore
Altre interazioni di Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Controindicata
- Baricitinib + Bcg vaccine live Controindicata
- Baricitinib + Tofacitinib Controindicata
- Baricitinib + Upadacitinib Controindicata
- Abatacept + Baricitinib Maggiore
- Adalimumab + Baricitinib Maggiore
Domande frequenti
Can I take Baricitinib with Benzathine penicillin g?
MediHelp rates the interaction as minor. Baricitinib and Benzathine penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Penicillins can inhibit OAT3, a transporter involved in baricitinib renal elimination, so baricitinib exposure may rise. Labeling advises against strong OAT3 inhibitors such as probenecid, but penicillin G is a much weaker inhibitor and benzathine penicillin gives low sustained levels, so the effect is likely small.
How serious is the interaction between Baricitinib and Benzathine penicillin g?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for baricitinib adverse effects such as infection and cytopenias as usual.
What other medicines interact with Benzathine penicillin g?
MediHelp also lists interactions of Benzathine penicillin g with, for example, Cholera vaccine, Microbiota, Omadacycline. The full list is on the Benzathine penicillin g page.
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