Drug interactions
Baricitinib + Benzathine penicillin g
Severity: Minor
Baricitinib and Benzathine penicillin g: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penicillins can inhibit OAT3, a transporter involved in baricitinib renal elimination, so baricitinib exposure may rise. Labeling advises against strong OAT3 inhibitors such as probenecid, but penicillin G is a much weaker inhibitor and benzathine penicillin gives low sustained levels, so the effect is likely small.
What this interaction means in plain words
Baricitinib and Benzathine penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Baricitinib belongs to Musculoskeletal; Benzathine penicillin g belongs to Anti Bacterial.
Why it happens
Possible weak OAT3 inhibition reducing renal tubular secretion of baricitinib.
What to do
No dose change is generally needed; monitor for baricitinib adverse effects such as infection and cytopenias as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Benzathine penicillin g
- Benzathine penicillin g + Cholera vaccine Moderate
- Benzathine penicillin g + Microbiota Moderate
- Benzathine penicillin g + Omadacycline Moderate
- Benzathine penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Amifampridine + Benzathine penicillin g Minor
Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Frequently asked questions
Can I take Baricitinib with Benzathine penicillin g?
MediHelp rates the interaction as minor. Baricitinib and Benzathine penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Penicillins can inhibit OAT3, a transporter involved in baricitinib renal elimination, so baricitinib exposure may rise. Labeling advises against strong OAT3 inhibitors such as probenecid, but penicillin G is a much weaker inhibitor and benzathine penicillin gives low sustained levels, so the effect is likely small.
How serious is the interaction between Baricitinib and Benzathine penicillin g?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for baricitinib adverse effects such as infection and cytopenias as usual.
What other medicines interact with Benzathine penicillin g?
MediHelp also lists interactions of Benzathine penicillin g with, for example, Cholera vaccine, Microbiota, Omadacycline. The full list is on the Benzathine penicillin g page.
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