Interazioni tra farmaci
Baricitinib + Upadacitinib
Gravità: Controindicata
Baricitinib and Upadacitinib: contraindicated interaction.
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Sintesi
Baricitinib and upadacitinib are both JAK inhibitors, so using them together duplicates therapy without proven benefit. Exposure to JAK-related adverse effects such as serious infection, thrombosis, cytopenias and lipid rise is doubled.
Cosa significa questa interazione in parole semplici
Baricitinib and Upadacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Baricitinib belongs to Musculoskeletal; Upadacitinib belongs to Musculoskeletal.
Perché avviene
Therapeutic duplication of JAK inhibition
Cosa fare
Do not combine; if switching between JAK inhibitors, stop the first agent before starting the second.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Controindicata
- Baricitinib + Bcg vaccine live Controindicata
- Baricitinib + Tofacitinib Controindicata
- Abatacept + Baricitinib Maggiore
- Adalimumab + Baricitinib Maggiore
- Ado-trastuzumab + Baricitinib Maggiore
Altre interazioni di Upadacitinib
- Abrocitinib + Upadacitinib Controindicata
- Adenovirus types 4 and 7 live + Upadacitinib Controindicata
- Bcg vaccine live + Upadacitinib Controindicata
- Cyclosporine + Upadacitinib Controindicata
- Dengue vaccine + Upadacitinib Controindicata
- Influenza virus vaccine quadrivalent intranasal + Upadacitinib Controindicata
Domande frequenti
Can I take Baricitinib with Upadacitinib?
MediHelp rates the interaction as contraindicated. Baricitinib and Upadacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Baricitinib and upadacitinib are both JAK inhibitors, so using them together duplicates therapy without proven benefit. Exposure to JAK-related adverse effects such as serious infection, thrombosis, cytopenias and lipid rise is doubled.
How serious is the interaction between Baricitinib and Upadacitinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; if switching between JAK inhibitors, stop the first agent before starting the second.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
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