Interazioni tra farmaci
Baricitinib + Penicillin g procaine-penicillin g
Gravità: Moderata
Baricitinib and Penicillin g procaine-penicillin g: moderate interaction.
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Sintesi
Penicillin G is eliminated by renal tubular secretion and can inhibit OAT3, the transporter involved in baricitinib clearance. This may raise baricitinib exposure, although the clinical effect is probably modest.
Cosa significa questa interazione in parole semplici
Baricitinib and Penicillin g procaine-penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baricitinib belongs to Musculoskeletal; Penicillin g procaine-penicillin g belongs to Anti Bacterial.
Perché avviene
Inhibition of renal OAT3-mediated tubular secretion of baricitinib by penicillin G reduces its elimination.
Cosa fare
Monitor for baricitinib adverse effects such as infection and cytopenias during penicillin courses. Dose reduction is generally not needed for short courses of penicillin.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Penicillin g procaine-penicillin g
- Amifampridine + Penicillin g procaine-penicillin g Moderata
- Cholera vaccine + Penicillin g procaine-penicillin g Moderata
- Microbiota + Penicillin g procaine-penicillin g Moderata
- Omadacycline + Penicillin g procaine-penicillin g Moderata
- Penicillin g procaine-penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderata
- Penicillin g procaine-penicillin g + Vadadustat Moderata
Altre interazioni di Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Controindicata
- Baricitinib + Bcg vaccine live Controindicata
- Baricitinib + Tofacitinib Controindicata
- Baricitinib + Upadacitinib Controindicata
- Abatacept + Baricitinib Maggiore
- Adalimumab + Baricitinib Maggiore
Domande frequenti
Can I take Baricitinib with Penicillin g procaine-penicillin g?
MediHelp rates the interaction as moderate. Baricitinib and Penicillin g procaine-penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Penicillin G is eliminated by renal tubular secretion and can inhibit OAT3, the transporter involved in baricitinib clearance. This may raise baricitinib exposure, although the clinical effect is probably modest.
How serious is the interaction between Baricitinib and Penicillin g procaine-penicillin g?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for baricitinib adverse effects such as infection and cytopenias during penicillin courses. Dose reduction is generally not needed for short courses of penicillin.
What other medicines interact with Penicillin g procaine-penicillin g?
MediHelp also lists interactions of Penicillin g procaine-penicillin g with, for example, Amifampridine, Cholera vaccine, Microbiota. The full list is on the Penicillin g procaine-penicillin g page.
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