Interazioni tra farmaci
Baricitinib + Vadadustat
Gravità: Moderata
Baricitinib and Vadadustat: moderate interaction.
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Sintesi
Vadadustat inhibits the organic anion transporter 3 (OAT3), which is a major route of renal elimination for baricitinib. Co-administration can raise baricitinib exposure and may increase dose-related adverse effects such as infection, cytopenias and lipid changes.
Cosa significa questa interazione in parole semplici
Baricitinib and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baricitinib belongs to Musculoskeletal; Vadadustat belongs to Endocrine.
Perché avviene
Vadadustat inhibits OAT3-mediated renal tubular secretion of baricitinib, reducing its clearance.
Cosa fare
Monitor for baricitinib adverse effects, including infections and blood counts. Consider baricitinib dose reduction according to its labeling for OAT3 inhibitors.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Controindicata
- Baricitinib + Bcg vaccine live Controindicata
- Baricitinib + Tofacitinib Controindicata
- Baricitinib + Upadacitinib Controindicata
- Abatacept + Baricitinib Maggiore
- Adalimumab + Baricitinib Maggiore
Altre interazioni di Vadadustat
- Atorvastatin + Vadadustat Moderata
- Balsalazide + Vadadustat Moderata
- Benzathine penicillin g + Vadadustat Moderata
- Calcium carbonate + Vadadustat Moderata
- Calcium + Vadadustat Moderata
- Cladribine + Vadadustat Moderata
Domande frequenti
Can I take Baricitinib with Vadadustat?
MediHelp rates the interaction as moderate. Baricitinib and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat inhibits the organic anion transporter 3 (OAT3), which is a major route of renal elimination for baricitinib. Co-administration can raise baricitinib exposure and may increase dose-related adverse effects such as infection, cytopenias and lipid changes.
How serious is the interaction between Baricitinib and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for baricitinib adverse effects, including infections and blood counts. Consider baricitinib dose reduction according to its labeling for OAT3 inhibitors.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
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