Interazioni tra farmaci
Bcg vaccine live + Leflunomide
Gravità: Controindicata
Bcg vaccine live and Leflunomide: contraindicated interaction.
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Sintesi
Leflunomide-induced immunosuppression can allow a live attenuated vaccine strain to replicate uncontrolled, causing disseminated infection. The vaccine response may also be diminished.
Cosa significa questa interazione in parole semplici
Bcg vaccine live and Leflunomide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Suppressed lymphocyte function impairs control of live attenuated organisms.
Cosa fare
Avoid live vaccines during leflunomide therapy and until drug elimination is confirmed (washout with cholestyramine if needed); give them before starting treatment.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Leflunomide
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Controindicata
- Leflunomide + Measles mumps and rubella vaccine live Controindicata
- Leflunomide + Measles mumps rubella and varicella vaccine live Controindicata
- Leflunomide + Measles vaccine Controindicata
- Leflunomide + Smallpox vaccine live Controindicata
- Alefacept + Leflunomide Maggiore
Domande frequenti
Can I take Bcg vaccine live with Leflunomide?
MediHelp rates the interaction as contraindicated. Bcg vaccine live and Leflunomide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Leflunomide-induced immunosuppression can allow a live attenuated vaccine strain to replicate uncontrolled, causing disseminated infection. The vaccine response may also be diminished.
How serious is the interaction between Bcg vaccine live and Leflunomide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during leflunomide therapy and until drug elimination is confirmed (washout with cholestyramine if needed); give them before starting treatment.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Leflunomide page.
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