Interazioni tra farmaci
Leflunomide + Smallpox vaccine live
Gravità: Controindicata
Leflunomide and Smallpox vaccine live: contraindicated interaction.
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Sintesi
Live vaccinia vaccine can cause progressive vaccinia and serious generalised infection in immunosuppressed patients. Leflunomide impairs the lymphocyte response needed to contain the virus. The vaccine response may also be inadequate.
Cosa significa questa interazione in parole semplici
Leflunomide and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Leflunomide's immunosuppression via dihydroorotate dehydrogenase inhibition permits uncontrolled replication of live vaccinia virus.
Cosa fare
Avoid live smallpox vaccine in patients taking leflunomide unless the risk of exposure clearly outweighs the risk, with specialist input. Consider drug elimination before vaccination when the vaccine is essential.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Leflunomide
- Bcg vaccine live + Leflunomide Controindicata
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Controindicata
- Leflunomide + Measles mumps and rubella vaccine live Controindicata
- Leflunomide + Measles mumps rubella and varicella vaccine live Controindicata
- Leflunomide + Measles vaccine Controindicata
- Alefacept + Leflunomide Maggiore
Domande frequenti
Can I take Leflunomide with Smallpox vaccine live?
MediHelp rates the interaction as contraindicated. Leflunomide and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Live vaccinia vaccine can cause progressive vaccinia and serious generalised infection in immunosuppressed patients. Leflunomide impairs the lymphocyte response needed to contain the virus. The vaccine response may also be inadequate.
How serious is the interaction between Leflunomide and Smallpox vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live smallpox vaccine in patients taking leflunomide unless the risk of exposure clearly outweighs the risk, with specialist input. Consider drug elimination before vaccination when the vaccine is essential.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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