Interazioni tra farmaci
Brentuximab vedotin + Isoniazid
Gravità: Moderata
Brentuximab vedotin and Isoniazid: moderate interaction.
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Sintesi
The cytotoxic component of brentuximab vedotin, MMAE, is metabolized by CYP3A4, so CYP3A4 inhibitors can raise its exposure and the risk of neutropenia. Isoniazid is only a weak inhibitor, so any effect is likely modest. Isoniazid also adds neuropathy and hepatotoxicity risk.
Cosa significa questa interazione in parole semplici
Brentuximab vedotin and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab vedotin belongs to Oncology; Isoniazid belongs to Anti Bacterial.
Perché avviene
Possible weak CYP3A4 inhibition by isoniazid increasing MMAE exposure, with additive neurotoxicity.
Cosa fare
Monitor blood counts for neutropenia and for peripheral neuropathy. Give pyridoxine as per isoniazid practice.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Isoniazid
- Bacillus calmette-guerin substrain tice + Isoniazid Maggiore
- Benzhydrocodone / acetaminophen + Isoniazid Maggiore
- Carbamazepine + Isoniazid Maggiore
- Didanosine + Isoniazid Maggiore
- Dihydroergotamine intranasal + Isoniazid Maggiore
- Dihydroergotamine + Isoniazid Maggiore
Altre interazioni di Brentuximab vedotin
- Bleomycin + Brentuximab vedotin Controindicata
- Brentuximab vedotin + Siponimod Maggiore
- Apalutamide + Brentuximab vedotin Moderata
- Brentuximab vedotin + Clarithromycin Moderata
- Brentuximab vedotin + Imatinib Moderata
- Brentuximab vedotin + Itraconazole Moderata
Domande frequenti
Can I take Brentuximab vedotin with Isoniazid?
MediHelp rates the interaction as moderate. Brentuximab vedotin and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The cytotoxic component of brentuximab vedotin, MMAE, is metabolized by CYP3A4, so CYP3A4 inhibitors can raise its exposure and the risk of neutropenia. Isoniazid is only a weak inhibitor, so any effect is likely modest. Isoniazid also adds neuropathy and hepatotoxicity risk.
How serious is the interaction between Brentuximab vedotin and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts for neutropenia and for peripheral neuropathy. Give pyridoxine as per isoniazid practice.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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