Interazioni tra farmaci
Brentuximab vedotin + Itraconazole
Gravità: Moderata
Brentuximab vedotin and Itraconazole: moderate interaction.
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Sintesi
Itraconazole can increase exposure to monomethyl auristatin E (MMAE), the cytotoxic component released from brentuximab vedotin. This may raise the risk of neutropenia and peripheral neuropathy.
Cosa significa questa interazione in parole semplici
Brentuximab vedotin and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab vedotin belongs to Oncology; Itraconazole belongs to Anti Fungals.
Perché avviene
Strong CYP3A4 inhibition (with possible P-gp inhibition) decreases MMAE clearance.
Cosa fare
Monitor closely for neutropenia, neuropathy and infection during co-therapy. Consider delaying or reducing brentuximab vedotin if toxicity appears.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Itraconazole
- Alfuzosin + Itraconazole Controindicata
- Alprazolam + Itraconazole Controindicata
- Avanafil + Itraconazole Controindicata
- Conivaptan + Itraconazole Controindicata
- Dihydroergotamine intranasal + Itraconazole Controindicata
- Dihydroergotamine + Itraconazole Controindicata
Altre interazioni di Brentuximab vedotin
- Bleomycin + Brentuximab vedotin Controindicata
- Brentuximab vedotin + Siponimod Maggiore
- Apalutamide + Brentuximab vedotin Moderata
- Brentuximab vedotin + Clarithromycin Moderata
- Brentuximab vedotin + Imatinib Moderata
- Brentuximab vedotin + Isoniazid Moderata
Domande frequenti
Can I take Brentuximab vedotin with Itraconazole?
MediHelp rates the interaction as moderate. Brentuximab vedotin and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole can increase exposure to monomethyl auristatin E (MMAE), the cytotoxic component released from brentuximab vedotin. This may raise the risk of neutropenia and peripheral neuropathy.
How serious is the interaction between Brentuximab vedotin and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for neutropenia, neuropathy and infection during co-therapy. Consider delaying or reducing brentuximab vedotin if toxicity appears.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
