Interazioni tra farmaci
Buprenorphine long-acting + Tizanidine
Gravità: Maggiore
Buprenorphine long-acting and Tizanidine: major interaction.
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Sintesi
Tizanidine with long-acting injectable buprenorphine may cause additive sedation, hypotension and respiratory depression. The depot prolongs exposure, so the effects are slow to resolve.
Cosa significa questa interazione in parole semplici
Buprenorphine long-acting and Tizanidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Additive CNS depression from alpha-2 agonism and opioid receptor partial agonism.
Cosa fare
Use only if other options are inadequate, starting tizanidine at a low dose. Monitor sedation, blood pressure and respiratory status.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Tizanidine
- Ciprofloxacin + Tizanidine Controindicata
- Fluvoxamine + Tizanidine Controindicata
- Pefloxacin + Tizanidine Controindicata
- Pipemidic acid + Tizanidine Controindicata
- Benzhydrocodone / acetaminophen + Tizanidine Maggiore
- Brexanolone + Tizanidine Maggiore
Domande frequenti
Can I take Buprenorphine long-acting with Tizanidine?
MediHelp rates the interaction as major. Buprenorphine long-acting and Tizanidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tizanidine with long-acting injectable buprenorphine may cause additive sedation, hypotension and respiratory depression. The depot prolongs exposure, so the effects are slow to resolve.
How serious is the interaction between Buprenorphine long-acting and Tizanidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only if other options are inadequate, starting tizanidine at a low dose. Monitor sedation, blood pressure and respiratory status.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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