Interazioni tra farmaci
Ciprofloxacin + Tizanidine
Gravità: Controindicata
Ciprofloxacin and Tizanidine: contraindicated interaction.
Ultimo aggiornamento Fonti: US FDA label
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Sintesi
Ciprofloxacin markedly increases tizanidine exposure, with studies showing roughly a ten-fold rise in peak concentration and about a 10-fold rise in AUC. This can cause severe hypotension, bradycardia, marked sedation and dizziness. The combination is contraindicated in tizanidine labeling.
Cosa significa questa interazione in parole semplici
Ciprofloxacin and Tizanidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ciprofloxacin belongs to Anti Bacterial; Tizanidine belongs to Musculoskeletal.
Perché avviene
Ciprofloxacin is a potent CYP1A2 inhibitor and blocks the main metabolic pathway of tizanidine, greatly increasing its systemic exposure.
Cosa fare
Do not co-administer. Choose an antibiotic that does not inhibit CYP1A2, or temporarily replace tizanidine with another antispasticity agent such as baclofen.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Riferimenti
Altre interazioni di Tizanidine
- Fluvoxamine + Tizanidine Controindicata
- Pefloxacin + Tizanidine Controindicata
- Pipemidic acid + Tizanidine Controindicata
- Benzhydrocodone / acetaminophen + Tizanidine Maggiore
- Brexanolone + Tizanidine Maggiore
- Buprenorphine long-acting + Tizanidine Maggiore
Altre interazioni di Ciprofloxacin
- Agomelatine + Ciprofloxacin Controindicata
- Ciprofloxacin + Fezolinetant Controindicata
- Ciprofloxacin + Thioridazine Controindicata
- Ciprofloxacin + Vandetanib Controindicata
- Alosetron + Ciprofloxacin Maggiore
- Aluminum hydroxide + Ciprofloxacin Maggiore
Domande frequenti
Can I take Ciprofloxacin with Tizanidine?
MediHelp rates the interaction as contraindicated. Ciprofloxacin and Tizanidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ciprofloxacin markedly increases tizanidine exposure, with studies showing roughly a ten-fold rise in peak concentration and about a 10-fold rise in AUC. This can cause severe hypotension, bradycardia, marked sedation and dizziness. The combination is contraindicated in tizanidine labeling.
How serious is the interaction between Ciprofloxacin and Tizanidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Choose an antibiotic that does not inhibit CYP1A2, or temporarily replace tizanidine with another antispasticity agent such as baclofen.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Fluvoxamine, Pefloxacin, Pipemidic acid. The full list is on the Tizanidine page.
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