Interazioni tra farmaci
Fluvoxamine + Tizanidine
Gravità: Controindicata
Fluvoxamine and Tizanidine: contraindicated interaction.
Ultimo aggiornamento Fonti: US FDA label
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Sintesi
Fluvoxamine markedly raises tizanidine concentrations, producing severe hypotension, bradycardia, profound sedation and psychomotor impairment. Tizanidine labeling contraindicates concomitant use with strong CYP1A2 inhibitors such as fluvoxamine. The effect is large and well documented.
Cosa significa questa interazione in parole semplici
Fluvoxamine and Tizanidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluvoxamine belongs to Central Nervous System; Tizanidine belongs to Musculoskeletal.
Perché avviene
Fluvoxamine is a potent CYP1A2 inhibitor and blocks the principal clearance pathway of tizanidine, causing a large increase in exposure.
Cosa fare
Do not combine. Use a different antispasticity or muscle-relaxant agent such as baclofen, or an antidepressant that does not strongly inhibit CYP1A2 (for example sertraline or escitalopram).
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Riferimenti
Altre interazioni di Tizanidine
- Ciprofloxacin + Tizanidine Controindicata
- Pefloxacin + Tizanidine Controindicata
- Pipemidic acid + Tizanidine Controindicata
- Benzhydrocodone / acetaminophen + Tizanidine Maggiore
- Brexanolone + Tizanidine Maggiore
- Buprenorphine long-acting + Tizanidine Maggiore
Altre interazioni di Fluvoxamine
- Agomelatine + Fluvoxamine Controindicata
- Alosetron + Fluvoxamine Controindicata
- Fezolinetant + Fluvoxamine Controindicata
- Fluvoxamine + Isocarboxazid Controindicata
- Fluvoxamine + Mavacamten Controindicata
- Fluvoxamine + Methylene blue Controindicata
Domande frequenti
Can I take Fluvoxamine with Tizanidine?
MediHelp rates the interaction as contraindicated. Fluvoxamine and Tizanidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fluvoxamine markedly raises tizanidine concentrations, producing severe hypotension, bradycardia, profound sedation and psychomotor impairment. Tizanidine labeling contraindicates concomitant use with strong CYP1A2 inhibitors such as fluvoxamine. The effect is large and well documented.
How serious is the interaction between Fluvoxamine and Tizanidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use a different antispasticity or muscle-relaxant agent such as baclofen, or an antidepressant that does not strongly inhibit CYP1A2 (for example sertraline or escitalopram).
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Pefloxacin, Pipemidic acid. The full list is on the Tizanidine page.
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