Interazioni tra farmaci
Pipemidic acid + Tizanidine
Gravità: Controindicata
Pipemidic acid and Tizanidine: contraindicated interaction.
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Sintesi
Pipemidic acid is a CYP1A2 inhibitor and can markedly raise tizanidine exposure. This may cause profound hypotension, bradycardia and sedation. Related fluoroquinolone CYP1A2 inhibitors are contraindicated with tizanidine.
Cosa significa questa interazione in parole semplici
Pipemidic acid and Tizanidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Inhibition of CYP1A2-mediated tizanidine metabolism increases plasma concentrations.
Cosa fare
Avoid the combination and choose an antibiotic that does not inhibit CYP1A2. If it cannot be avoided, use an alternative muscle relaxant.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Tizanidine
- Ciprofloxacin + Tizanidine Controindicata
- Fluvoxamine + Tizanidine Controindicata
- Pefloxacin + Tizanidine Controindicata
- Benzhydrocodone / acetaminophen + Tizanidine Maggiore
- Brexanolone + Tizanidine Maggiore
- Buprenorphine long-acting + Tizanidine Maggiore
Domande frequenti
Can I take Pipemidic acid with Tizanidine?
MediHelp rates the interaction as contraindicated. Pipemidic acid and Tizanidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Pipemidic acid is a CYP1A2 inhibitor and can markedly raise tizanidine exposure. This may cause profound hypotension, bradycardia and sedation. Related fluoroquinolone CYP1A2 inhibitors are contraindicated with tizanidine.
How serious is the interaction between Pipemidic acid and Tizanidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antibiotic that does not inhibit CYP1A2. If it cannot be avoided, use an alternative muscle relaxant.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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