Interazioni tra farmaci
Bupropion + Phenelzine
Gravità: Controindicata
Bupropion and Phenelzine: contraindicated interaction.
Ultimo aggiornamento Fonti: US FDA label
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Sintesi
Bupropion is contraindicated with MAO inhibitors because of the risk of hypertensive reactions and neurotoxicity. Labeling requires at least 14 days between stopping an MAOI such as phenelzine and starting bupropion. Seizure risk may also be raised.
Cosa significa questa interazione in parole semplici
Bupropion and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bupropion belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Perché avviene
Bupropion inhibits noradrenaline and dopamine reuptake while MAO inhibition increases catecholamine stores, producing excessive adrenergic stimulation; bupropion also lowers seizure threshold.
Cosa fare
Do not combine; wait at least 14 days after stopping phenelzine before starting bupropion, and at least 14 days after bupropion before starting phenelzine is a conservative approach. Use a different smoking cessation or antidepressant strategy during MAOI treatment.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Riferimenti
Altre interazioni di Bupropion
- Bupropion + Isocarboxazid Controindicata
- Bupropion + Linezolid Controindicata
- Bupropion + Rasagiline Controindicata
- Bupropion + Selegiline Controindicata
- Bupropion + Selegiline transdermal Controindicata
- Bupropion + Thioridazine Controindicata
Altre interazioni di Phenelzine
- 5-HTP + Phenelzine Controindicata
- Amitriptyline + Phenelzine Controindicata
- Amoxapine + Phenelzine Controindicata
- Atomoxetine + Phenelzine Controindicata
- Benzphetamine + Phenelzine Controindicata
- Brimonidine + Phenelzine Controindicata
Domande frequenti
Can I take Bupropion with Phenelzine?
MediHelp rates the interaction as contraindicated. Bupropion and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Bupropion is contraindicated with MAO inhibitors because of the risk of hypertensive reactions and neurotoxicity. Labeling requires at least 14 days between stopping an MAOI such as phenelzine and starting bupropion. Seizure risk may also be raised.
How serious is the interaction between Bupropion and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; wait at least 14 days after stopping phenelzine before starting bupropion, and at least 14 days after bupropion before starting phenelzine is a conservative approach. Use a different smoking cessation or antidepressant strategy during MAOI treatment.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Rasagiline. The full list is on the Bupropion page.
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