Interazioni tra farmaci
Bupropion + Thioridazine
Gravità: Controindicata
Bupropion and Thioridazine: contraindicated interaction.
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Sintesi
Thioridazine is metabolised by CYP2D6, and bupropion is a strong inhibitor of this enzyme. Higher thioridazine levels can cause marked QT prolongation and torsades de pointes. Thioridazine labeling contraindicates drugs that inhibit its metabolism.
Cosa significa questa interazione in parole semplici
Bupropion and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bupropion belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Perché avviene
Bupropion inhibits CYP2D6, raising thioridazine levels and QT prolongation risk.
Cosa fare
Do not combine; use an alternative antidepressant or antipsychotic. If exposure occurs, obtain an ECG and check potassium and magnesium.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Bupropion
- Bupropion + Isocarboxazid Controindicata
- Bupropion + Linezolid Controindicata
- Bupropion + Phenelzine Controindicata
- Bupropion + Rasagiline Controindicata
- Bupropion + Selegiline Controindicata
- Bupropion + Selegiline transdermal Controindicata
Altre interazioni di Thioridazine
- Abiraterone + Thioridazine Controindicata
- Adagrasib + Thioridazine Controindicata
- Amiodarone + Thioridazine Controindicata
- Amisulpride + Thioridazine Controindicata
- Amitriptyline + Thioridazine Controindicata
- Amoxapine + Thioridazine Controindicata
Domande frequenti
Can I take Bupropion with Thioridazine?
MediHelp rates the interaction as contraindicated. Bupropion and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine is metabolised by CYP2D6, and bupropion is a strong inhibitor of this enzyme. Higher thioridazine levels can cause marked QT prolongation and torsades de pointes. Thioridazine labeling contraindicates drugs that inhibit its metabolism.
How serious is the interaction between Bupropion and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use an alternative antidepressant or antipsychotic. If exposure occurs, obtain an ECG and check potassium and magnesium.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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