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Bupropion-naltrexone + Phenelzine

Gravità: Controindicata

Bupropion-naltrexone and Phenelzine: contraindicated interaction.

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Sintesi

Phenelzine (an irreversible non-selective MAO inhibitor) slows catecholamine breakdown, while bupropion blocks reuptake of dopamine and noradrenaline. The combination can produce hypertensive crisis, agitation and seizures; labelling for bupropion prohibits concurrent MAOI therapy.

Cosa significa questa interazione in parole semplici

Bupropion-naltrexone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Bupropion-naltrexone belongs to Miscellaneous; Phenelzine belongs to Central Nervous System.

Livello di evidenza: High

Perché avviene

MAO inhibition combined with dopamine and noradrenaline reuptake inhibition causes excess catecholamine activity

Cosa fare

Do not use together. Wait at least 14 days after stopping phenelzine before starting the other drug; allow at least a week after stopping bupropion before starting an MAOI.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Bupropion-naltrexone with Phenelzine?

MediHelp rates the interaction as contraindicated. Bupropion-naltrexone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenelzine (an irreversible non-selective MAO inhibitor) slows catecholamine breakdown, while bupropion blocks reuptake of dopamine and noradrenaline. The combination can produce hypertensive crisis, agitation and seizures; labelling for bupropion prohibits concurrent MAOI therapy.

How serious is the interaction between Bupropion-naltrexone and Phenelzine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Wait at least 14 days after stopping phenelzine before starting the other drug; allow at least a week after stopping bupropion before starting an MAOI.

What other medicines interact with Bupropion-naltrexone?

MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.

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