Interazioni tra farmaci
Bupropion-naltrexone + Hydromorphone
Gravità: Controindicata
Bupropion-naltrexone and Hydromorphone: contraindicated interaction.
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Sintesi
Naltrexone blocks opioid receptors, so it antagonizes hydromorphone analgesia and can precipitate withdrawal in opioid-dependent patients. Hydromorphone is not primarily CYP2D6 dependent, so the pharmacokinetic effect of bupropion is minor by comparison.
Cosa significa questa interazione in parole semplici
Bupropion-naltrexone and Hydromorphone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bupropion-naltrexone belongs to Miscellaneous; Hydromorphone belongs to Musculoskeletal.
Perché avviene
Naltrexone competitively antagonizes mu opioid receptors, opposing hydromorphone effects.
Cosa fare
Avoid concurrent use; the product is contraindicated with chronic opioid therapy. Allow an adequate opioid-free interval before starting.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Controindicata
- Bupropion-naltrexone + Isocarboxazid Controindicata
- Bupropion-naltrexone + Linezolid Controindicata
- Bupropion-naltrexone + Phenelzine Controindicata
- Bupropion-naltrexone + Rasagiline Controindicata
- Bupropion-naltrexone + Selegiline Controindicata
Altre interazioni di Hydromorphone
- Alvimopan + Hydromorphone Controindicata
- Hydromorphone + Isocarboxazid Controindicata
- Hydromorphone + Olanzapine / samidorphan Controindicata
- Hydromorphone + Phenelzine Controindicata
- Hydromorphone + Tranylcypromine Controindicata
- Alfentanil + Hydromorphone Maggiore
Domande frequenti
Can I take Bupropion-naltrexone with Hydromorphone?
MediHelp rates the interaction as contraindicated. Bupropion-naltrexone and Hydromorphone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Naltrexone blocks opioid receptors, so it antagonizes hydromorphone analgesia and can precipitate withdrawal in opioid-dependent patients. Hydromorphone is not primarily CYP2D6 dependent, so the pharmacokinetic effect of bupropion is minor by comparison.
How serious is the interaction between Bupropion-naltrexone and Hydromorphone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; the product is contraindicated with chronic opioid therapy. Allow an adequate opioid-free interval before starting.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Isocarboxazid, Linezolid. The full list is on the Bupropion-naltrexone page.
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