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Bupropion-naltrexone + Hydrocodone

Gravità: Controindicata

Bupropion-naltrexone and Hydrocodone: contraindicated interaction.

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Sintesi

Naltrexone is an opioid antagonist and blocks the analgesic effect of hydrocodone, and can precipitate withdrawal in opioid-dependent patients. Bupropion also inhibits CYP2D6 and may reduce conversion of hydrocodone to hydromorphone, and the combination carries seizure and serotonergic concerns.

Cosa significa questa interazione in parole semplici

Bupropion-naltrexone and Hydrocodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Bupropion-naltrexone belongs to Miscellaneous; Hydrocodone belongs to Musculoskeletal.

Livello di evidenza: High

Perché avviene

Naltrexone competitively antagonizes opioid receptors; bupropion inhibits CYP2D6 and lowers seizure threshold.

Cosa fare

Avoid combining; the bupropion-naltrexone product is contraindicated with chronic opioid use. Allow an opioid-free interval of 7 to 10 days before starting it.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Bupropion-naltrexone with Hydrocodone?

MediHelp rates the interaction as contraindicated. Bupropion-naltrexone and Hydrocodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Naltrexone is an opioid antagonist and blocks the analgesic effect of hydrocodone, and can precipitate withdrawal in opioid-dependent patients. Bupropion also inhibits CYP2D6 and may reduce conversion of hydrocodone to hydromorphone, and the combination carries seizure and serotonergic concerns.

How serious is the interaction between Bupropion-naltrexone and Hydrocodone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; the bupropion-naltrexone product is contraindicated with chronic opioid use. Allow an opioid-free interval of 7 to 10 days before starting it.

What other medicines interact with Bupropion-naltrexone?

MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydromorphone, Isocarboxazid, Linezolid. The full list is on the Bupropion-naltrexone page.

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