Interazioni tra farmaci
Candesartan-hydrochlorothiazide + Ethacrynic acid
Gravità: Maggiore
Candesartan-hydrochlorothiazide and Ethacrynic acid: major interaction.
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Sintesi
Ethacrynic acid is a potent loop diuretic and combining it with a thiazide can cause marked diuresis, volume depletion, hypotension, hypokalemia and hyponatremia. Candesartan may add to hypotension and renal impairment in volume-depleted patients.
Cosa significa questa interazione in parole semplici
Candesartan-hydrochlorothiazide and Ethacrynic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Ethacrynic acid belongs to Cardiovascular.
Perché avviene
Sequential nephron blockade with a loop diuretic and a thiazide produces additive natriuresis and potassium loss.
Cosa fare
Monitor electrolytes, renal function, weight and blood pressure closely, and reduce diuretic doses if volume depletion develops. Replace potassium and magnesium as needed.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Controindicata
- Candesartan-hydrochlorothiazide + Dofetilide Controindicata
- Candesartan-hydrochlorothiazide + Sparsentan Controindicata
- Acemetacin + Candesartan-hydrochlorothiazide Maggiore
- Amifostine + Candesartan-hydrochlorothiazide Maggiore
- Amiloride + Candesartan-hydrochlorothiazide Maggiore
Altre interazioni di Ethacrynic acid
Domande frequenti
Can I take Candesartan-hydrochlorothiazide with Ethacrynic acid?
MediHelp rates the interaction as major. Candesartan-hydrochlorothiazide and Ethacrynic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ethacrynic acid is a potent loop diuretic and combining it with a thiazide can cause marked diuresis, volume depletion, hypotension, hypokalemia and hyponatremia. Candesartan may add to hypotension and renal impairment in volume-depleted patients.
How serious is the interaction between Candesartan-hydrochlorothiazide and Ethacrynic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, renal function, weight and blood pressure closely, and reduce diuretic doses if volume depletion develops. Replace potassium and magnesium as needed.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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