Vai al contenuto

Interazioni tra farmaci

Carbamazepine + Propylthiouracil

Gravità: Maggiore

Carbamazepine and Propylthiouracil: major interaction.

Ultimo aggiornamento

Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.

Il contenuto clinico di questa pagina è disponibile solo in inglese.

Sintesi

Both drugs can cause agranulocytosis, so combined use may heighten the risk of severe neutropenia and infection.

Cosa significa questa interazione in parole semplici

Carbamazepine and Propylthiouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Carbamazepine belongs to Central Nervous System; Propylthiouracil belongs to Endocrine.

Livello di evidenza: Low

Perché avviene

Additive pharmacodynamic myelotoxicity, as each drug independently can cause idiosyncratic agranulocytosis.

Cosa fare

Check a baseline and periodic white cell count with differential, and counsel the patient to report fever or sore throat at once. Stop the offending drug if neutropenia develops, and consider an alternative anticonvulsant.

Cosa chiedere al farmacista

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Per gli utenti Pro+

Sblocca la pagina completa

Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Carbamazepine e Propylthiouracil, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.

Domande frequenti

Can I take Carbamazepine with Propylthiouracil?

MediHelp rates the interaction as major. Carbamazepine and Propylthiouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can cause agranulocytosis, so combined use may heighten the risk of severe neutropenia and infection.

How serious is the interaction between Carbamazepine and Propylthiouracil?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline and periodic white cell count with differential, and counsel the patient to report fever or sore throat at once. Stop the offending drug if neutropenia develops, and consider an alternative anticonvulsant.

What other medicines interact with Carbamazepine?

MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.

Monografie complete, posologie e verifica delle interazioni nell'app MediHelp

Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.

Sfoglia dalla A alla Z · Interazioni tra farmaci

Scarica l'app Accedi