Interazioni tra farmaci
Propylthiouracil + Sodium iodide i-131
Gravità: Maggiore
Propylthiouracil and Sodium iodide i-131: major interaction.
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Sintesi
Antithyroid drugs reduce thyroid uptake of radioiodine, so the therapeutic radiation dose delivered to the gland may be inadequate. Treatment failure or the need for repeat dosing may result.
Cosa significa questa interazione in parole semplici
Propylthiouracil and Sodium iodide i-131 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Propylthiouracil inhibits thyroid peroxidase and hormone synthesis, which lowers thyroidal radioiodine uptake and retention.
Cosa fare
Stop propylthiouracil several days before I-131 administration, typically 3 to 4 days per labeling, and do not give them together. Restart afterward according to the treating specialist's plan and monitor thyroid function.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Domande frequenti
Can I take Propylthiouracil with Sodium iodide i-131?
MediHelp rates the interaction as major. Propylthiouracil and Sodium iodide i-131 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antithyroid drugs reduce thyroid uptake of radioiodine, so the therapeutic radiation dose delivered to the gland may be inadequate. Treatment failure or the need for repeat dosing may result.
How serious is the interaction between Propylthiouracil and Sodium iodide i-131?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop propylthiouracil several days before I-131 administration, typically 3 to 4 days per labeling, and do not give them together. Restart afterward according to the treating specialist's plan and monitor thyroid function.
What other medicines interact with Propylthiouracil?
MediHelp also lists interactions of Propylthiouracil with, for example, Carbamazepine, Clozapine, Methimazole. The full list is on the Propylthiouracil page.
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