Interazioni tra farmaci
Propylthiouracil + Valoctocogene roxaparvovec
Gravità: Maggiore
Propylthiouracil and Valoctocogene roxaparvovec: major interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Valoctocogene roxaparvovec commonly raises liver enzymes, and propylthiouracil is a known cause of serious liver injury. Combined use may increase hepatotoxicity risk and can complicate interpretation of enzyme rises after gene therapy.
Cosa significa questa interazione in parole semplici
Propylthiouracil and Valoctocogene roxaparvovec can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Propylthiouracil belongs to Endocrine; Valoctocogene roxaparvovec belongs to Miscellaneous.
Perché avviene
Additive hepatotoxicity risk from propylthiouracil and gene therapy-related hepatocellular effects.
Cosa fare
Prefer an alternative antithyroid agent such as methimazole where possible. If used, monitor ALT and other liver tests frequently.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Propylthiouracil e Valoctocogene roxaparvovec, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Propylthiouracil
- Carbamazepine + Propylthiouracil Maggiore
- Clozapine + Propylthiouracil Maggiore
- Methimazole + Propylthiouracil Maggiore
- Pexidartinib + Propylthiouracil Maggiore
- Pretomanid + Propylthiouracil Maggiore
- Propylthiouracil + Sodium iodide i-131 Maggiore
Altre interazioni di Valoctocogene roxaparvovec
Domande frequenti
Can I take Propylthiouracil with Valoctocogene roxaparvovec?
MediHelp rates the interaction as major. Propylthiouracil and Valoctocogene roxaparvovec can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Valoctocogene roxaparvovec commonly raises liver enzymes, and propylthiouracil is a known cause of serious liver injury. Combined use may increase hepatotoxicity risk and can complicate interpretation of enzyme rises after gene therapy.
How serious is the interaction between Propylthiouracil and Valoctocogene roxaparvovec?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antithyroid agent such as methimazole where possible. If used, monitor ALT and other liver tests frequently.
What other medicines interact with Propylthiouracil?
MediHelp also lists interactions of Propylthiouracil with, for example, Carbamazepine, Clozapine, Methimazole. The full list is on the Propylthiouracil page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
