Interazioni tra farmaci
Apraclonidine + Isocarboxazid
Gravità: Controindicata
Apraclonidine and Isocarboxazid: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Apraclonidine labeling lists MAO inhibitors as a contraindication. Theoretically, altered catecholamine handling could cause blood pressure changes, although ophthalmic exposure is small.
Cosa significa questa interazione in parole semplici
Apraclonidine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apraclonidine belongs to Cardiovascular; Isocarboxazid belongs to Central Nervous System.
Perché avviene
Mechanism is not firmly established; MAO inhibition may alter catecholamine metabolism and potentiate the systemic effects of the alpha-2 agonist.
Cosa fare
Avoid apraclonidine in patients on isocarboxazid and use another intraocular pressure-lowering agent. Follow the labeled contraindication.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Isocarboxazid
- 5-HTP + Isocarboxazid Controindicata
- Amitriptyline + Isocarboxazid Controindicata
- Amobarbital + Isocarboxazid Controindicata
- Amoxapine + Isocarboxazid Controindicata
- Atomoxetine + Isocarboxazid Controindicata
- Benzphetamine + Isocarboxazid Controindicata
Altre interazioni di Apraclonidine
- Apraclonidine + Linezolid Maggiore
- Apraclonidine + Phenelzine Maggiore
- Apraclonidine + Rasagiline Maggiore
- Apraclonidine + Selegiline Maggiore
- Apraclonidine + Tranylcypromine Maggiore
Domande frequenti
Can I take Apraclonidine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Apraclonidine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Apraclonidine labeling lists MAO inhibitors as a contraindication. Theoretically, altered catecholamine handling could cause blood pressure changes, although ophthalmic exposure is small.
How serious is the interaction between Apraclonidine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid apraclonidine in patients on isocarboxazid and use another intraocular pressure-lowering agent. Follow the labeled contraindication.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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