Interazioni tra farmaci
Caspofungin + Phenytoin
Gravità: Moderata
Caspofungin and Phenytoin: moderate interaction.
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Sintesi
Phenytoin, an enzyme inducer, may lower caspofungin exposure. Reduced antifungal exposure could compromise treatment of invasive fungal infection.
Cosa significa questa interazione in parole semplici
Caspofungin and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Caspofungin belongs to Anti Fungals; Phenytoin belongs to Central Nervous System.
Perché avviene
Phenytoin induces hepatic enzymes and possibly transport pathways, increasing caspofungin clearance.
Cosa fare
Consider caspofungin 70 mg daily after the loading dose in adults when given with phenytoin, and monitor clinical response.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Caspofungin
- Apalutamide + Caspofungin Moderata
- Carbamazepine + Caspofungin Moderata
- Caspofungin + Cyclosporin Moderata
- Caspofungin + Cyclosporine Moderata
- Caspofungin + Dexamethasone Moderata
- Caspofungin + Efavirenz Moderata
Altre interazioni di Phenytoin
- Artemether / lumefantrine + Phenytoin Controindicata
- Bictegravir + Phenytoin Controindicata
- Cabotegravir + Phenytoin Controindicata
- Doravirine + Phenytoin Controindicata
- Elbasvir / grazoprevir + Phenytoin Controindicata
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Controindicata
Domande frequenti
Can I take Caspofungin with Phenytoin?
MediHelp rates the interaction as moderate. Caspofungin and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin, an enzyme inducer, may lower caspofungin exposure. Reduced antifungal exposure could compromise treatment of invasive fungal infection.
How serious is the interaction between Caspofungin and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider caspofungin 70 mg daily after the loading dose in adults when given with phenytoin, and monitor clinical response.
What other medicines interact with Caspofungin?
MediHelp also lists interactions of Caspofungin with, for example, Apalutamide, Carbamazepine, Cyclosporin. The full list is on the Caspofungin page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
