Interazioni tra farmaci
Cefixime + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Gravità: Moderata
Cefixime and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
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Sintesi
Sodium picosulfate is a prodrug that must be converted to its active form by colonic bacteria. Antibiotics that suppress gut flora may reduce this conversion and lead to a less effective bowel cleansing before colonoscopy.
Cosa significa questa interazione in parole semplici
Cefixime and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perché avviene
Antibiotic suppression of colonic bacteria reduces conversion of picosulfate to its active laxative metabolite.
Cosa fare
If possible, avoid starting the antibiotic until after the bowel preparation has been completed. Assess the quality of bowel cleansing and be prepared to use an additional preparation if it is inadequate.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Cefixime
- Cefixime + Typhoid vaccine live Maggiore
- Cefixime + Cholera vaccine Moderata
- Cefixime + Kanamycin Moderata
- Cefixime + Microbiota Moderata
- Cefixime + Plazomicin Moderata
- Cefixime + Warfarin Moderata
Domande frequenti
Can I take Cefixime with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Cefixime and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium picosulfate is a prodrug that must be converted to its active form by colonic bacteria. Antibiotics that suppress gut flora may reduce this conversion and lead to a less effective bowel cleansing before colonoscopy.
How serious is the interaction between Cefixime and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If possible, avoid starting the antibiotic until after the bowel preparation has been completed. Assess the quality of bowel cleansing and be prepared to use an additional preparation if it is inadequate.
What other medicines interact with Cefixime?
MediHelp also lists interactions of Cefixime with, for example, Typhoid vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefixime page.
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