Interazioni tra farmaci
Cefixime + Kanamycin
Gravità: Moderata
Cefixime and Kanamycin: moderate interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Aminoglycosides such as kanamycin are nephrotoxic and ototoxic, and cephalosporins have occasionally been associated with additive renal injury when given alongside them. Cefixime is itself rarely nephrotoxic and is renally cleared, so reduced renal function may raise exposure to both drugs.
Cosa significa questa interazione in parole semplici
Cefixime and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perché avviene
Possible additive nephrotoxicity, with impaired renal function reducing clearance of both agents.
Cosa fare
Monitor serum creatinine and urine output, and consider kanamycin levels and hearing or vestibular symptoms during therapy. Adjust doses to renal function and keep the patient well hydrated.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Cefixime e Kanamycin, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Cefixime
- Cefixime + Typhoid vaccine live Maggiore
- Cefixime + Cholera vaccine Moderata
- Cefixime + Microbiota Moderata
- Cefixime + Plazomicin Moderata
- Cefixime + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderata
- Cefixime + Warfarin Moderata
Domande frequenti
Can I take Cefixime with Kanamycin?
MediHelp rates the interaction as moderate. Cefixime and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides such as kanamycin are nephrotoxic and ototoxic, and cephalosporins have occasionally been associated with additive renal injury when given alongside them. Cefixime is itself rarely nephrotoxic and is renally cleared, so reduced renal function may raise exposure to both drugs.
How serious is the interaction between Cefixime and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output, and consider kanamycin levels and hearing or vestibular symptoms during therapy. Adjust doses to renal function and keep the patient well hydrated.
What other medicines interact with Cefixime?
MediHelp also lists interactions of Cefixime with, for example, Typhoid vaccine live, Cholera vaccine, Microbiota. The full list is on the Cefixime page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
