Interazioni tra farmaci
Cefixime + Plazomicin
Gravità: Moderata
Cefixime and Plazomicin: moderate interaction.
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Sintesi
Plazomicin carries a boxed warning for nephrotoxicity, ototoxicity and neuromuscular blockade. Cefixime is renally cleared and may add to renal burden or accumulate if kidney function declines during plazomicin therapy.
Cosa significa questa interazione in parole semplici
Cefixime and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefixime belongs to Anti Bacterial; Plazomicin belongs to Anti Bacterial.
Perché avviene
Possible additive nephrotoxicity, with reduced renal clearance of both drugs if kidney function falls.
Cosa fare
Monitor serum creatinine before and during treatment, and adjust cefixime dosing if creatinine clearance falls. Use plazomicin therapeutic drug monitoring and watch for hearing or balance changes.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Cefixime
- Cefixime + Typhoid vaccine live Maggiore
- Cefixime + Cholera vaccine Moderata
- Cefixime + Kanamycin Moderata
- Cefixime + Microbiota Moderata
- Cefixime + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderata
- Cefixime + Warfarin Moderata
Altre interazioni di Plazomicin
- Cefaclor + Plazomicin Moderata
- Cefadroxil + Plazomicin Moderata
- Cefalexin + Plazomicin Moderata
- Cefazolin + Plazomicin Moderata
- Cefditoren + Plazomicin Moderata
- Cefepime + Plazomicin Moderata
Domande frequenti
Can I take Cefixime with Plazomicin?
MediHelp rates the interaction as moderate. Cefixime and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Plazomicin carries a boxed warning for nephrotoxicity, ototoxicity and neuromuscular blockade. Cefixime is renally cleared and may add to renal burden or accumulate if kidney function declines during plazomicin therapy.
How serious is the interaction between Cefixime and Plazomicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine before and during treatment, and adjust cefixime dosing if creatinine clearance falls. Use plazomicin therapeutic drug monitoring and watch for hearing or balance changes.
What other medicines interact with Cefixime?
MediHelp also lists interactions of Cefixime with, for example, Typhoid vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefixime page.
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