Interazioni tra farmaci
Charcoal + Methotrexate
Gravità: Moderata
Charcoal and Methotrexate: moderate interaction.
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Sintesi
Activated charcoal adsorbs methotrexate in the gut and interrupts its enterohepatic circulation, decreasing exposure. This can reduce therapeutic effect with routine use but can help limit toxicity in overdose.
Cosa significa questa interazione in parole semplici
Charcoal and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Charcoal belongs to Gastrointestinal Tract; Methotrexate belongs to Oncology.
Perché avviene
Charcoal binds methotrexate in the gastrointestinal lumen, reducing absorption and biliary reabsorption.
Cosa fare
Do not give charcoal with oral methotrexate therapy; separate doses by several hours if charcoal is needed. In toxicity, charcoal may be used alongside leucovorin and monitoring of methotrexate levels and renal function.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Charcoal
- Charcoal + Citalopram Moderata
- Charcoal + Digoxin Moderata
- Charcoal + Leflunomide Moderata
- Charcoal + Theophylline Moderata
- Charcoal + Tiratricol Moderata
- Acarbose + Charcoal Minore
Altre interazioni di Methotrexate
- Acitretin + Methotrexate Controindicata
- Adenovirus types 4 and 7 live + Methotrexate Controindicata
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Controindicata
- Ketorolac + Methotrexate Controindicata
- Measles mumps and rubella vaccine live + Methotrexate Controindicata
- Measles mumps and rubella vaccine + Methotrexate Controindicata
Domande frequenti
Can I take Charcoal with Methotrexate?
MediHelp rates the interaction as moderate. Charcoal and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Activated charcoal adsorbs methotrexate in the gut and interrupts its enterohepatic circulation, decreasing exposure. This can reduce therapeutic effect with routine use but can help limit toxicity in overdose.
How serious is the interaction between Charcoal and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give charcoal with oral methotrexate therapy; separate doses by several hours if charcoal is needed. In toxicity, charcoal may be used alongside leucovorin and monitoring of methotrexate levels and renal function.
What other medicines interact with Charcoal?
MediHelp also lists interactions of Charcoal with, for example, Citalopram, Digoxin, Leflunomide. The full list is on the Charcoal page.
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