Interazioni tra farmaci
Clomipramine + Methylene blue
Gravità: Controindicata
Clomipramine and Methylene blue: contraindicated interaction.
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Sintesi
Methylene blue inhibits monoamine oxidase A, and combining it with a strongly serotonergic tricyclic can cause serotonin syndrome. Severe cases involve hyperthermia, rigidity, seizures and altered consciousness.
Cosa significa questa interazione in parole semplici
Clomipramine and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
MAO-A inhibition by methylene blue combined with serotonin reuptake inhibition by clomipramine leads to excess serotonin.
Cosa fare
Avoid unless methylene blue is needed for a life-threatening condition. If it is, stop clomipramine and monitor for serotonin toxicity; do not restart for at least 24 hours after the last methylene blue dose.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Clomipramine
- Arsenic trioxide + Clomipramine Controindicata
- Clomipramine + Dofetilide Controindicata
- Clomipramine + Droperidol Controindicata
- Clomipramine + Isocarboxazid Controindicata
- Clomipramine + Pentamidine Controindicata
- Clomipramine + Phenelzine Controindicata
Domande frequenti
Can I take Clomipramine with Methylene blue?
MediHelp rates the interaction as contraindicated. Clomipramine and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylene blue inhibits monoamine oxidase A, and combining it with a strongly serotonergic tricyclic can cause serotonin syndrome. Severe cases involve hyperthermia, rigidity, seizures and altered consciousness.
How serious is the interaction between Clomipramine and Methylene blue?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless methylene blue is needed for a life-threatening condition. If it is, stop clomipramine and monitor for serotonin toxicity; do not restart for at least 24 hours after the last methylene blue dose.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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