Interazioni tra farmaci
Clomipramine + Pentamidine
Gravità: Controindicata
Clomipramine and Pentamidine: contraindicated interaction.
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Sintesi
Both drugs can prolong the QT interval, and systemic pentamidine has been associated with torsades de pointes. Combined use raises the risk of life-threatening ventricular arrhythmia.
Cosa significa questa interazione in parole semplici
Clomipramine and Pentamidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clomipramine belongs to Central Nervous System; Pentamidine belongs to Anti Parasitic.
Perché avviene
Additive prolongation of cardiac repolarization through effects on cardiac ion channels.
Cosa fare
Avoid concurrent use; choose a non-QT-prolonging alternative for one of the drugs. If pentamidine is essential, withhold clomipramine where feasible and monitor ECG and electrolytes.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Clomipramine
- Arsenic trioxide + Clomipramine Controindicata
- Clomipramine + Dofetilide Controindicata
- Clomipramine + Droperidol Controindicata
- Clomipramine + Isocarboxazid Controindicata
- Clomipramine + Methylene blue Controindicata
- Clomipramine + Phenelzine Controindicata
Altre interazioni di Pentamidine
- Desipramine + Pentamidine Controindicata
- Dronedarone + Pentamidine Controindicata
- Moxifloxacin + Pentamidine Controindicata
- Nortriptyline + Pentamidine Controindicata
- Pentamidine + Pimozide Controindicata
- Pentamidine + Thioridazine Controindicata
Domande frequenti
Can I take Clomipramine with Pentamidine?
MediHelp rates the interaction as contraindicated. Clomipramine and Pentamidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can prolong the QT interval, and systemic pentamidine has been associated with torsades de pointes. Combined use raises the risk of life-threatening ventricular arrhythmia.
How serious is the interaction between Clomipramine and Pentamidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; choose a non-QT-prolonging alternative for one of the drugs. If pentamidine is essential, withhold clomipramine where feasible and monitor ECG and electrolytes.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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