Interazioni tra farmaci
Clomipramine + Phenelzine
Gravità: Controindicata
Clomipramine and Phenelzine: contraindicated interaction.
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Sintesi
Clomipramine is a potent serotonin and noradrenaline reuptake inhibitor, and phenelzine (an irreversible non-selective MAO inhibitor) blocks monoamine breakdown. Serotonin syndrome and hypertensive crisis are the main dangers.
Cosa significa questa interazione in parole semplici
Clomipramine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clomipramine belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Perché avviene
Monoamine reuptake inhibition plus MAO inhibition
Cosa fare
Do not use together. Wait at least 14 days after stopping phenelzine before starting the other drug; leave about 2 weeks after stopping clomipramine before starting an irreversible MAOI.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Clomipramine
- Arsenic trioxide + Clomipramine Controindicata
- Clomipramine + Dofetilide Controindicata
- Clomipramine + Droperidol Controindicata
- Clomipramine + Isocarboxazid Controindicata
- Clomipramine + Methylene blue Controindicata
- Clomipramine + Pentamidine Controindicata
Altre interazioni di Phenelzine
- 5-HTP + Phenelzine Controindicata
- Amitriptyline + Phenelzine Controindicata
- Amoxapine + Phenelzine Controindicata
- Atomoxetine + Phenelzine Controindicata
- Benzphetamine + Phenelzine Controindicata
- Brimonidine + Phenelzine Controindicata
Domande frequenti
Can I take Clomipramine with Phenelzine?
MediHelp rates the interaction as contraindicated. Clomipramine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clomipramine is a potent serotonin and noradrenaline reuptake inhibitor, and phenelzine (an irreversible non-selective MAO inhibitor) blocks monoamine breakdown. Serotonin syndrome and hypertensive crisis are the main dangers.
How serious is the interaction between Clomipramine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Wait at least 14 days after stopping phenelzine before starting the other drug; leave about 2 weeks after stopping clomipramine before starting an irreversible MAOI.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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