Riferimento farmaci
Sodium oxybate
Sodium oxybate is a medicine in the class central nervous system. It is used for narcolepsy.
- Classe del farmaco: Central Nervous System
- Indicato per: narcolepsy
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Central Nervous System
- Codice ATC
- N07XX04
- Forme farmaceutiche comuni
- sospensione orale, soluzione
- Dosaggi comuni
- 50%
- Interazioni note
- 99 (Controindicata: 17 · Maggiore: 79 · Moderata: 3)
- Nomi commerciali
- 3
- Paesi e mercati
- 2
Per cosa si usa
Come agisce
CNS depressant. Mechanism in narcolepsy is unknown. It is the sodium salt of GHB, a metabolite of GABA; therapeutic effects are hypothesized to be mediated through GABA B actions at noradrenergic, dopaminergic and thalamocortical neurons.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Narcolepsy (cataplexy or EDS): start 4.5 g per night orally in two divided doses (2.25 g at bedtime and 2.25 g 2.5 to 4 hours later); increase by 1.5 g per night at weekly intervals; effective range 6 g to 9 g per night; doses higher than 9 g per night not studied.
Gravidanza e allattamento
- Gravidanza
- Unknown No adequate human data. Rat pre/postnatal study showed increased stillbirths and decreased offspring viability and growth at a clinically relevant dose.
- Allattamento
- Unknown GHB is excreted in human milk; insufficient information on infant risk. Weigh breastfeeding benefits against maternal need.
Effetti indesiderati segnalati
- Nausea
- Dizziness
- Vomiting
- Somnolence
- Enuresis
- Tremor
Avvertenze in evidenza
- CNS depression: Xyrem is a CNS depressant; obtundation and clinically significant respiratory depression occurred in adults at recommended doses.
Controindicazioni
- Combination with sedative hypnotics.
- Combination with alcohol.
- Succinic semialdehyde dehydrogenase deficiency.
Chi deve prestare attenzione
- Concurrent use with other CNS depressants may increase risk of respiratory depression, hypotension, profound sedation, syncope and death; consider dose reduction or discontinuation.
- No hazardous activities requiring mental alertness for at least 6 hours after dosing.
- May impair respiratory drive; increased central apneas and desaturation observed in adults and children.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (99)
- Alprazolam + Sodium oxybate Contraindicated
- Amobarbital + Sodium oxybate Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Eszopiclone + Sodium oxybate Contraindicated
- Methadone + Sodium oxybate Contraindicated
- Midazolam + Sodium oxybate Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Domande frequenti
What is Sodium oxybate used for?
Sodium oxybate is a medicine in the class central nervous system. It is used for Narcolepsy.
What side effects have been reported with Sodium oxybate?
Nausea, Dizziness, Vomiting, Somnolence, Enuresis, Tremor. Serious warning: CNS depression: Xyrem is a CNS depressant; obtundation and clinically significant respiratory depression occurred in adults at recommended doses.
Can Sodium oxybate be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No adequate human data. Rat pre/postnatal study showed increased stillbirths and decreased offspring viability and growth at a clinically relevant dose. Breastfeeding: Unknown. GHB is excreted in human milk; insufficient information on infant risk. Weigh breastfeeding benefits against maternal need.
What does Sodium oxybate interact with?
MediHelp lists 99 known interactions for Sodium oxybate. Contraindicated: 17 · Major: 79 · Moderate: 3. The most serious include Alprazolam, Amobarbital, Butorphanol.
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