Interazioni tra farmaci
Colchicine + Danicopan
Gravità: Moderata
Colchicine and Danicopan: moderate interaction.
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Sintesi
Danicopan inhibits P-glycoprotein and can raise concentrations of P-gp substrates such as colchicine. Because colchicine has a narrow therapeutic index, increased exposure may cause toxicity.
Cosa significa questa interazione in parole semplici
Colchicine and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colchicine belongs to Genitourinary; Danicopan belongs to Miscellaneous.
Perché avviene
P-glycoprotein inhibition by danicopan reduces colchicine efflux.
Cosa fare
Consider reducing the colchicine dose and monitor for gastrointestinal, neuromuscular and hematologic toxicity, particularly in renal impairment.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Colchicine
- Clarithromycin + Colchicine Controindicata
- Cobicistat + Colchicine Controindicata
- Colchicine + Cyclosporine Controindicata
- Colchicine + Ensitrelvir Controindicata
- Colchicine + Levoketoconazole Controindicata
- Colchicine + Nirmatrelvir Controindicata
Altre interazioni di Danicopan
- Amiodarone + Danicopan Moderata
- Apixaban + Danicopan Moderata
- Atorvastatin + Danicopan Moderata
- Brentuximab + Danicopan Moderata
- Carvedilol + Danicopan Moderata
- Cladribine + Danicopan Moderata
Domande frequenti
Can I take Colchicine with Danicopan?
MediHelp rates the interaction as moderate. Colchicine and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-glycoprotein and can raise concentrations of P-gp substrates such as colchicine. Because colchicine has a narrow therapeutic index, increased exposure may cause toxicity.
How serious is the interaction between Colchicine and Danicopan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the colchicine dose and monitor for gastrointestinal, neuromuscular and hematologic toxicity, particularly in renal impairment.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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