Drug interactions
Colchicine + Danicopan
Severity: Moderate
Colchicine and Danicopan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and can raise concentrations of P-gp substrates such as colchicine. Because colchicine has a narrow therapeutic index, increased exposure may cause toxicity.
What this interaction means in plain words
Colchicine and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colchicine belongs to Genitourinary; Danicopan belongs to Miscellaneous.
Why it happens
P-glycoprotein inhibition by danicopan reduces colchicine efflux.
What to do
Consider reducing the colchicine dose and monitor for gastrointestinal, neuromuscular and hematologic toxicity, particularly in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Colchicine with Danicopan?
MediHelp rates the interaction as moderate. Colchicine and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-glycoprotein and can raise concentrations of P-gp substrates such as colchicine. Because colchicine has a narrow therapeutic index, increased exposure may cause toxicity.
How serious is the interaction between Colchicine and Danicopan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the colchicine dose and monitor for gastrointestinal, neuromuscular and hematologic toxicity, particularly in renal impairment.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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