Interazioni tra farmaci
Cyclosporin + Glycerol phenylbutyrate
Gravità: Moderata
Cyclosporin and Glycerol phenylbutyrate: moderate interaction.
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Sintesi
Glycerol phenylbutyrate is a weak CYP3A4 inducer and may lower cyclosporine concentrations. Reduced exposure could compromise immunosuppression.
Cosa significa questa interazione in parole semplici
Cyclosporin and Glycerol phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Glycerol phenylbutyrate belongs to Miscellaneous.
Perché avviene
Weak induction of CYP3A4 increases cyclosporine metabolism.
Cosa fare
Monitor cyclosporine trough levels after starting or stopping glycerol phenylbutyrate and adjust the dose if needed.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Controindicata
- Aliskiren + Cyclosporin Controindicata
- Bcg vaccine live + Cyclosporin Controindicata
- Bosentan + Cyclosporin Controindicata
- Cidofovir + Cyclosporin Controindicata
- Cyclosporin + Dengue vaccine Controindicata
Altre interazioni di Glycerol phenylbutyrate
- Dexamethasone + Glycerol phenylbutyrate Maggiore
- Glycerol phenylbutyrate + Sodium valproate Maggiore
- Glycerol phenylbutyrate + Valproic acid Maggiore
- Dexamethasone-neomycin-polymyxin + Glycerol phenylbutyrate Moderata
- Dexamethasone-tobramycin + Glycerol phenylbutyrate Moderata
- Fludrocortisone + Glycerol phenylbutyrate Moderata
Domande frequenti
Can I take Cyclosporin with Glycerol phenylbutyrate?
MediHelp rates the interaction as moderate. Cyclosporin and Glycerol phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glycerol phenylbutyrate is a weak CYP3A4 inducer and may lower cyclosporine concentrations. Reduced exposure could compromise immunosuppression.
How serious is the interaction between Cyclosporin and Glycerol phenylbutyrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels after starting or stopping glycerol phenylbutyrate and adjust the dose if needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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