Interazioni tra farmaci
Cyclosporin + Revefenacin
Gravità: Maggiore
Cyclosporin and Revefenacin: major interaction.
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Sintesi
Cyclosporine inhibits hepatic uptake transporters OATP1B1 and OATP1B3, which can raise systemic exposure to the active metabolite of inhaled revefenacin. Higher exposure could increase anticholinergic adverse effects such as dry mouth, urinary retention and tachycardia.
Cosa significa questa interazione in parole semplici
Cyclosporin and Revefenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Revefenacin belongs to Respiratory.
Perché avviene
Cyclosporine inhibits OATP1B1/OATP1B3-mediated uptake, reducing hepatic clearance of revefenacin's active metabolite.
Cosa fare
Coadministration is not recommended per labeling; choose an alternative long-acting bronchodilator if cyclosporine is needed. If unavoidable, monitor for anticholinergic effects.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Controindicata
- Aliskiren + Cyclosporin Controindicata
- Bcg vaccine live + Cyclosporin Controindicata
- Bosentan + Cyclosporin Controindicata
- Cidofovir + Cyclosporin Controindicata
- Cyclosporin + Dengue vaccine Controindicata
Altre interazioni di Revefenacin
- Indacaterol-glycopyrronium + Revefenacin Maggiore
- Revefenacin + Rifampicin Maggiore
- Revefenacin + Tiotropium Maggiore
- Atropine + Revefenacin Moderata
- Benztropine + Revefenacin Moderata
- Darifenacin + Revefenacin Moderata
Domande frequenti
Can I take Cyclosporin with Revefenacin?
MediHelp rates the interaction as major. Cyclosporin and Revefenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine inhibits hepatic uptake transporters OATP1B1 and OATP1B3, which can raise systemic exposure to the active metabolite of inhaled revefenacin. Higher exposure could increase anticholinergic adverse effects such as dry mouth, urinary retention and tachycardia.
How serious is the interaction between Cyclosporin and Revefenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Coadministration is not recommended per labeling; choose an alternative long-acting bronchodilator if cyclosporine is needed. If unavoidable, monitor for anticholinergic effects.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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