Interazioni tra farmaci
Cyclosporin + Voclosporin
Gravità: Controindicata
Cyclosporin and Voclosporin: contraindicated interaction.
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Sintesi
Both are calcineurin inhibitors, so combining them gives duplicate immunosuppression and additive nephrotoxicity, hyperkalemia and infection risk. Cyclosporine also inhibits CYP3A4 and raises voclosporin exposure.
Cosa significa questa interazione in parole semplici
Cyclosporin and Voclosporin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cyclosporin belongs to Miscellaneous; Voclosporin belongs to Miscellaneous.
Perché avviene
Additive calcineurin inhibition with pharmacodynamic overlap, plus cyclosporine-mediated CYP3A4 inhibition that increases voclosporin levels.
Cosa fare
Do not use the two calcineurin inhibitors together. Use only one agent and allow appropriate washout when switching.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Controindicata
- Aliskiren + Cyclosporin Controindicata
- Bcg vaccine live + Cyclosporin Controindicata
- Bosentan + Cyclosporin Controindicata
- Cidofovir + Cyclosporin Controindicata
- Cyclosporin + Dengue vaccine Controindicata
Altre interazioni di Voclosporin
- Clarithromycin + Voclosporin Controindicata
- Ensitrelvir + Voclosporin Controindicata
- Itraconazole + Voclosporin Controindicata
- Ketoconazole + Voclosporin Controindicata
- Posaconazole + Voclosporin Controindicata
- Voclosporin + Voriconazole Controindicata
Domande frequenti
Can I take Cyclosporin with Voclosporin?
MediHelp rates the interaction as contraindicated. Cyclosporin and Voclosporin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are calcineurin inhibitors, so combining them gives duplicate immunosuppression and additive nephrotoxicity, hyperkalemia and infection risk. Cyclosporine also inhibits CYP3A4 and raises voclosporin exposure.
How serious is the interaction between Cyclosporin and Voclosporin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use the two calcineurin inhibitors together. Use only one agent and allow appropriate washout when switching.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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