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Daprodustat + Hydrochlorothiazide-irbesartan

Gravità: Moderata

Daprodustat and Hydrochlorothiazide-irbesartan: moderate interaction.

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Sintesi

Irbesartan is reported to be a CYP2C8 inhibitor, and daprodustat is cleared mainly by CYP2C8. Exposure to daprodustat may therefore rise, increasing the risk of excessive erythropoietic response and related cardiovascular or thrombotic events.

Cosa significa questa interazione in parole semplici

Daprodustat and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Daprodustat belongs to Endocrine; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.

Livello di evidenza: Low

Perché avviene

Inhibition of CYP2C8-mediated metabolism of daprodustat raises its plasma concentrations.

Cosa fare

Monitor hemoglobin closely when irbesartan is started or stopped and adjust the daprodustat dose accordingly. Consider a lower daprodustat starting dose if the combination is initiated together.

Cosa chiedere al farmacista

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Daprodustat with Hydrochlorothiazide-irbesartan?

MediHelp rates the interaction as moderate. Daprodustat and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Irbesartan is reported to be a CYP2C8 inhibitor, and daprodustat is cleared mainly by CYP2C8. Exposure to daprodustat may therefore rise, increasing the risk of excessive erythropoietic response and related cardiovascular or thrombotic events.

How serious is the interaction between Daprodustat and Hydrochlorothiazide-irbesartan?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin closely when irbesartan is started or stopped and adjust the daprodustat dose accordingly. Consider a lower daprodustat starting dose if the combination is initiated together.

What other medicines interact with Hydrochlorothiazide-irbesartan?

MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.

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